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Enabling an ultra-specific lysosomal polarity fluorescence response via intramolecular π-π stacking-mediated
Jiaqi Su1, Chunbai Xiang1, Jiao Lu2
1Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. luzhiyun@scu.edu.cn.
Chemical Communications (Cambridge, England)
|June 11, 2025
Abstract:
Designing ultra-specific polar fluorescent probes through the strategy of intramolecular π-π interactions was reported. Based on this strategy, a high-performance lysosomal polarity probe, named P-DOTPA, was developed. It exhibits high specificity, ultra-high sensitivity, near-infrared emission, and the ability to generate superoxide radicals (O2-˙) under irradiation.
