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Published on: June 4, 2017
Allergic Risk Among the Children in Southern China: The Association of Influencing Factors with the Allergen
Jieyan Ma1, Genfeng Wu2, Heming Huang1
1Clinical Laboratory, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College), Shenzhen, Guangdong, People's Republic of China.
Insights
Accurate allergy diagnosis in children is challenging. This study found mites, cow
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Diagnostics
- Immunology
Background:
- Pediatric allergy diagnosis is complicated by atypical clinical symptoms in children.
- Identifying allergen distribution is crucial for effective diagnosis and management of pediatric allergic diseases.
Purpose of the Study:
- To investigate the distribution of 28 common allergens in children with suspected allergies.
- To analyze the relationship between allergen distribution, age, and clinical manifestations in pediatric allergy patients.
Main Methods:
- Serum-specific IgE levels were analyzed in 12,292 children with suspected allergies in Shenzhen.
- Relevance analysis was performed to identify factors influencing allergen distribution.
Main Results:
- The overall allergen distribution was 66.36%, with mites, cow's milk, and egg white being the most prevalent.
- Indoor allergens were more common than outdoor allergens, and significant cross-reactivity was observed among certain allergens.
- Allergen prevalence varied with age, and specific allergens were associated with particular allergic conditions (e.g., mites with allergic rhinitis/conjunctivitis, milk/egg with dermatitis).
Conclusions:
- Age and allergen cross-reactivity are critical factors in diagnosing childhood allergies.
- Understanding age-specific sensitivities and cross-reactions aids in comprehensive allergy assessment.
- Results can inform pediatricians in developing targeted prevention and management strategies.
Background:
Due to the inability of children with allergies to exhibit appropriate clinical symptoms, pediatricians often face the challenge of accurately diagnosing allergic diseases in children. Identifying the distribution of allergens is essential for the effective diagnosis and treatment of allergic diseases.
Methods:
We investigated the distribution of 28 allergens among 12,292 suspected allergic children in Shenzhen, whose serum-specific IgE was subjected to relevance analysis with influencing factors.
Results:
The results showed the overall allergen distribution was 66.36%. Mite, cow's milk, and egg white were the most prevalent allergens. Indoor allergens are significantly higher than outdoor allergens. There was extensive cross-reactivity among homologous species of allergens such as crustacean allergens, plant-derived allergens, etc. A 14KDa profilin as a common ingredient is suspected to be the main cause of the cross-reactivity among these plant-derived allergens. The frequencies of mite, cow's milk and egg white showed different trends with growing age, indicating that the frequencies of allergens are age-related. Various mechanisms of immune systems of children mature at different ages. We found that the proportion of mite sensitivity was highest in children with allergic rhinitis and conjunctivitis, while the proportion of cow's milk and egg white sensitivity was higher in children with allergic dermatitis such as eczema and urticaria.
Conclusion:
Age and cross-reactivity play important roles in diagnosing allergies in children. Children at different ages exhibit varying sensitivities to different types of allergens, and identifying cross-reactions helps to comprehensively understand children's allergic status. Pediatricians can develop corresponding prevention and management measures based on allergen results and clinical symptoms.
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