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Updated: Jun 12, 2025
Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations
Published on: March 29, 2017
Endo IV-assisted cascade amplification for ultrasensitive TdT detection in acute lymphoblastic leukemia
Juan Wang1, Jia Wu2, Yue Zhou3
1Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China.
None:
This study developed a highly sensitive fluorescence biosensor based on an Endo IV-fluorescent probe cascade amplification system, achieving a three-tier signal amplification. The detection limit is 9.6 × 10-5 U μL-1, with a linear range of 0-0.3 U μL-1. This technology offers excellent sensitivity, simplicity, and low cost, providing a powerful tool for the clinical diagnosis of acute lymphoblastic leukemia.
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