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Updated: Jun 13, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Direct Pd-Catalyzed β-C(sp3)-H Hydroxylation of Aliphatic Carboxylic Acids
Sourjya Mal1, Tianxiao Xu1, Manuel van Gemmeren1
1Otto Diels-Institut für Organische Chemie, Christian-Albrechts Universität zu Kiel, Otto-Hahn-Platz 4, 24118 Kiel, Germany.
Abstract:
β-Hydroxy carbonyl scaffolds are of paramount importance due to their presence in a variety of natural products and bioactive molecules. In this study, we present a direct palladium-catalyzed β-C(sp3)-H hydroxylation of aliphatic carboxylic acids. The reported method employs convenient and readily available TBHP as an oxidant and provides an efficient, one-step route to a diverse range of β-hydroxy acids. Key aspects include the compatibility of this method with challenging α-non-quaternary carboxylic acids as substrates and excellent functional group tolerance. This newly developed method is expected to prove useful for generating compound libraries relevant to multiple disciplines.
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