Photochemically Driven Ruthenium-Catalyzed Regioselective C-H Functionalization of Indoles with Alcohols to Access
Jayaveerapandiyan Barathkumar1, Rebaka Vara Prasad1, Subbiah Nagarajan1
1Assembled Organic & Hybrid Materials Lab, Department of Chemistry, National Institute of Technology Warangal, Hanamkonda, Telangana 506004, India.
Abstract:
We herein report a photochemical C-H functionalization reaction between indoles and alcohols to access indole-3-carbaldehyde and bis(indolyl)methane scaffolds using a ruthenium catalyst. Optimization studies revealed that the tuning in the ruthenium catalyst structure rendered indole-3-carbaldehyde in good yields, whereas the direct use of RuCl3·3H2O delivered bis(indolyl)methanes in good to excellent yields. These reactions proceed under operationally simple green conditions, offering a broad substrate scope.
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