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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Related Experiment Video

Updated: Jun 14, 2025

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
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Positron Emission Tomography Imaging in Vasculitis.

Kornelis S M van der Geest1, Berend G C Slijkhuis2, Alessandro Tomelleri3

  • 1Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, the Netherlands.

Heart Failure Clinics
|June 12, 2025
PubMed
Summary

[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) is crucial for diagnosing and monitoring large and medium vessel vasculitis. Advances in scanner technology enhance its ability to assess disease extent, with new tracers promising more detailed immune cell detection.

Keywords:
FDG-PET/CTHeartNovel tracersVasculitis

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Area of Science:

  • Immunology
  • Radiology
  • Nuclear Medicine

Background:

  • Systemic vasculitides are autoimmune diseases targeting blood vessels.
  • Large and medium vessel vasculitis require accurate diagnostic and monitoring tools.

Purpose of the Study:

  • To highlight the role of FDG-PET/CT in vasculitis management.
  • To discuss the impact of technological advancements on FDG-PET/CT efficacy.
  • To explore future directions with novel imaging tracers.

Main Methods:

  • Utilizing [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT).
  • Comparing FDG-PET/CT findings with other vascular imaging modalities.
  • Evaluating the performance of newer generation PET/CT scanners.

Main Results:

  • FDG-PET/CT is effective for diagnosis and therapeutic monitoring of large and medium vessel vasculitis.
  • Improved scanner resolution and sensitivity enhance disease extent assessment.
  • FDG-PET/CT offers complementary information to other imaging techniques.

Conclusions:

  • FDG-PET/CT is a valuable tool in the management of systemic vasculitides.
  • Technological progress is increasing the diagnostic accuracy of FDG-PET/CT.
  • Future developments in tracers will enable more precise detection of vascular inflammation.