Clinical Performance and Optical Quality of a Non-Diffractive Extended-Depth-of-Focus Intraocular Lens in Patients...

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Optics

Background:

• Cataract surgery and refractive lensectomy are common procedures.
• Intraocular lenses (IOLs) aim to restore vision after these procedures.
• Extended-depth-of-focus (EDOF) IOLs offer a broader range of vision compared to monofocal IOLs.

Purpose of the Study:

• To evaluate the clinical performance and optical quality of the Asqelio™ EDOF IOL.
• To compare the Asqelio™ EDOF IOL with a standard monofocal IOL.
• To assess visual acuities, contrast sensitivity, and patient-reported outcomes.

Main Methods:

• Prospective observational, case-control study.
• Bilateral implantation of Asqelio™ EDOF IOL (Study Group) or TECNIS® 1-Piece ZCB00 monofocal IOL (Control Group).
• Postoperative assessment at 3 months included visual acuities, refraction, contrast sensitivity, optical scatter index (OSI), aberrations, and patient questionnaires.

Main Results:

• 91% of EDOF eyes achieved ±0.50 D of target refraction.
• Binocular uncorrected visual acuities: distance 0.00, intermediate 0.13, near 0.32 logMAR.
• Similar contrast sensitivity and OSI; lower higher-order aberrations in EDOF group.
• High patient satisfaction with minimal visual disturbances and no adverse events.

Conclusions:

• Asqelio™ EDOF IOL demonstrates good refractive predictability and functional vision across distances.
• Optical quality and contrast sensitivity are comparable to monofocal IOLs.
• The Asqelio™ EDOF IOL is a viable option for patients desiring extended functional vision with few side effects.