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Related Concept Videos

Integrins01:10

Integrins

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Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
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Intracellular Signaling Affects Focal Adhesions01:17

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Activation of Integrins01:15

Activation of Integrins

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Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
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Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
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G-protein Coupled Receptors01:21

G-protein Coupled Receptors

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Updated: Jun 16, 2025

Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis
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Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis

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Integrin Alpha8 Beta1 (81): An In-Depth Review of an Overlooked RGD-Binding Receptor.

Iman Ezzat1, Marisa Zallocchi1

  • 1Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.

Biocell : Official Journal of the Sociedades Latinoamericanas De Microscopia Electronica ... Et. Al
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Integrin alpha 8 beta 1 (α8β1) is crucial for organ development, particularly in the kidney and inner ear. This receptor plays a role in tissue repair, cancer, and hearing function, offering potential therapeutic applications.

Keywords:
RGD binding integrinTransmembrane receptorcytoskeleton

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Area of Science:

  • Cellular Biology
  • Developmental Biology
  • Molecular Medicine

Background:

  • Integrins are transmembrane receptors mediating cell-extracellular matrix interactions, vital for tissue development and function.
  • The integrin family includes 24 heterodimeric combinations, with only 8 recognizing the arginine-glycine-aspartate (RGD) motif.
  • Integrin alpha 8 beta 1 (α8β1) is a key RGD-binding integrin, particularly in contractile cells, and is regulated by Ras homolog gene family member A (RHOA).

Purpose of the Study:

  • To review recent advances in understanding the function of integrin alpha 8 beta 1 (α8β1) during organ development.
  • To explore the role of α8β1 in kidney and inner ear development.
  • To discuss the involvement of α8β1 in injury, disease, mesenchymal to epithelial transition in cancer, and hearing function.

Main Methods:

  • This review synthesizes recent research findings on α8β1 function.
  • Literature search focused on studies related to organogenesis, disease pathology, and cancer development involving α8β1.
  • Analysis of the molecular mechanisms and functional consequences of α8β1 signaling.

Main Results:

  • α8β1 is a critical modulator in kidney and inner ear development.
  • The receptor is implicated in tissue repair processes following injury.
  • α8β1 plays a significant role in mesenchymal to epithelial transition during cancer progression and is essential for hearing function.

Conclusions:

  • Integrin α8β1 is a pivotal regulator in multiple developmental processes, including kidney and inner ear formation.
  • Dysregulation of α8β1 is associated with disease states, including cancer and hearing impairment.
  • α8β1 holds promise as a diagnostic and therapeutic target for various diseases.