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Genetic Markers as Predictors of Prognosis and Treatment Response in Patients with Oral Cancer: A Prospective Study
P Rishal Mohammed1, Mitali Dash2, Seema Pati3
1College of Dental Medicine, Qatar University, Doha, Qatar.
Introduction:
"Oral squamous cell carcinoma (OSCC)" is a prevalent malignancy globally, with significant morbidity and mortality. Genetic markers are emerging as vital tools in predicting prognosis and treatment responses. This research explores genetic markers' role in OSCC prognosis and therapeutic outcomes.
Methods:
This prospective research analyzed 150 OSCC patients, investigating the prognostic value of three genetic markers: TP53 mutations, miR-31 expression, and "mismatch repair (MMR)" protein loss.
Results:
Patients with TP53 mutations exhibited lower survival rates (P < 0.05). Elevated miR-31 was associated with aggressive disease (P < 0.01), while MMR loss correlated with advanced tumor stages (P < 0.001).
Conclusion:
Genetic markers, like TP53 mutations, miR-31, and MMR loss, can effectively predict prognosis and treatment responses in OSCC. Integrating these markers into clinical practice can enhance personalized treatment strategies.
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