Related Experiment Video
Updated: Jun 14, 2025

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
Bioactive Rosane and Podocarpane Diterpenoids From the Whole Plant of Jatropha curcas L
Zhong-Dan Liang1, Yan-Ling Tang1, Chao-Jun Li1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.
Abstract:
One previously undescribed rosane diterpenoid (1) and 13 known ones (2-14) were isolated from the whole plant of Jatropha curcas L. The relative configuration 1 was determined by NMR calculation combined with DP4+ probability analysis, and its absolute configuration (AC) was further determined by ECD calculation. The final structure was further confirmed by single crystal x-ray diffraction. The biological testing revealed that compounds 5 and 14 possessed inhibitory effects on NLRP3 inflammasome with IC50 values of 8.1 ± 0.3 and 9.7 ± 0.4 µM. Further investigation exhibited that compound 5 has an obvious effect on inhibiting pyroptosis.
More Related Videos
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
Related Concept Videos
Carboxylic Acid Derivatives: Overview
Seed Structure and Early Development of the Sporophyte
The Calvin Benson Cycle
C4 Pathway and CAM
C4 Pathway
The C4 pathway is used by plants such as...
Prodrugs
Prodrugs help overcome...
Organic Compounds