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Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

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Related Experiment Video

Updated: Jun 16, 2025

Simple, Affordable, and Modular Patterning of Cells using DNA

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

DNA-programmed responsive microorganism assembly with controlled patterns and behaviors.

Yuhan Kong¹, Qi Du¹, Dan Zhao^1,2

¹Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo and Biosensing, Hunan Provincial Key Laboratory of Bio-macromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

Science Advances

|June 13, 2025

Summary

This summary is machine-generated.

Researchers engineered programmable microbial communities using functional DNA as surface receptors. This synthetic biology advance allows precise control over microbial patterns and behaviors for dynamic biofunctions.

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Last Updated: Jun 16, 2025

Simple, Affordable, and Modular Patterning of Cells using DNA

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Area of Science:

Synthetic biology
Microbial engineering
Biotechnology

Background:

Engineering multicellular microbial communities is crucial for synthetic biology and medicine.
Current methods for controlling microbial interactions lack specificity and require engineered organisms.

Purpose of the Study:

To develop a method for programming microorganism adhesions using functional DNA.
To enable precise spatial control and stimuli-responsive behaviors in engineered microbial communities.

Main Methods:

Functional DNA was used as programmable surface receptors to modify microorganisms.
Metabolic labeling and hydrophobic insertion were employed for DNA modification.
Diverse microbial species, including bacteria and spores, were functionalized with DNA.

Main Results:

Precise spatial control of microbial assemblies (bi- and tricomponent) was achieved, forming diverse morphologies.
Stimuli-responsive clustering was demonstrated using DNA-based mechanisms like aptamers and strand displacement.
Engineered communities exhibited dynamic biofunctions such as controlled biofilm formation and altered antibiotic sensitivity.

Conclusions:

Functional DNA provides a versatile platform for programming microbial interactions and engineering complex communities.
This approach enables the creation of living microbial systems with dynamic, externally triggered biofunctions.
The findings advance synthetic biology applications in medicine and biotechnology.