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High Economic Burden Yet Low Clinical Value: Why Is so Much Sucralfate Prescribed?
Neha Wadhavkar1, Laura Varnum2, Steven F Moss3
1Department of Internal Medicine, Brown University, Providence, Rhode Island, USA.
Basic & Clinical Pharmacology & Toxicology
|June 14, 2025
Summary
Sucralfate remains prescribed for acid-dyspeptic conditions despite limited evidence. Its cost is comparable to other acid reducers, but further studies are needed to confirm its true clinical efficacy.
Area of Science:
- Gastroenterology
- Pharmacoeconomics
Background:
- Sucralfate has been a long-standing prescription for upper gastrointestinal symptoms.
- More effective acid-dyspeptic medications like proton pump inhibitors and histamine H2-receptor antagonists are available.
Purpose of the Study:
- To review the evidence supporting sucralfate's approval and continued use.
- To conduct a cost analysis of sucralfate compared to other acid-reducing medications.
Main Methods:
- Literature review of evidence for sucralfate.
- Cost analysis utilizing the ClinCalc database.
Main Results:
- The evidence base for sucralfate's efficacy is limited.
- Sucralfate's financial impact is comparable to famotidine, lansoprazole, and ranitidine.
Conclusions:
- Further research is required to determine the actual clinical effectiveness of sucralfate.
- The continued prescription of sucralfate should be re-evaluated pending further efficacy studies.
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