Related Experiment Video
Updated: Jun 16, 2025
08:10
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
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The senescent heart and atrial fibrillation
Amitabh C Pandey1, Ghassan Bidaoui2, Hadi Younes2
1Department of Cardiology, Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana; Southeast Louisiana Veterans Health Care System, New Orleans, Louisiana.
Heart Rhythm
|June 14, 2025
Summary
Cellular senescence, a hallmark of aging, contributes to atrial myopathy and atrial fibrillation (AF). This review explores the link between aging, cardiac senescence, and AF, discussing potential senolytic and senomorphic therapies.
Area of Science:
- Cardiology
- Gerontology
- Molecular Biology
Background:
- Atrial fibrillation (AF) prevalence is rising globally, driven by population aging.
- Aging contributes to atrial myopathy, the substrate for AF, but mechanisms are unclear.
- Cellular senescence, a key aging process, is implicated in aging-related diseases.
Purpose of the Study:
- To review the molecular basis of cardiac senescence and its secretory phenotype.
- To explore the relationship between cardiac senescence, atrial myopathy, and AF.
- To discuss senolytic and senomorphic agents for AF treatment.
Main Methods:
- Literature review of cardiac senescence and AF.
- Analysis of molecular pathways linking senescence to atrial remodeling.
- Examination of pre-clinical studies on senotherapies in cardiology.
Main Results:
- Cellular senescence, with its unique secretome, contributes to atrial myopathy.
- Renin-angiotensin-aldosterone system activation, mitochondrial dysfunction, and epigenetic changes are involved.
- Senolytic and senomorphic agents show potential in pre-clinical models.
Conclusions:
- Cellular senescence is a critical factor in age-related atrial myopathy and AF.
- Targeting senescence pathways offers a promising therapeutic strategy for AF.
- Further research is needed to translate senotherapies into clinical practice for AF.
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