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Innervating 3D in vitro models: bioengineering and design blueprints.

Mariana-Tomás de Carvalho1, Margarida Henriques-Pereira1, Maria V Monteiro1

  • 1Department of Chemistry, Centre for Research in Ceramics and Composite Materials (CICECO)-Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Cellularis Biomodels, Parque de Ciência e Inovação (PCI) Creative Science Park, Aveiro Region, Via do Conhecimento, 3830-352 Ílhavo, Portugal.

Trends in Biotechnology
|June 14, 2025
PubMed
Summary
This summary is machine-generated.

Researchers are developing advanced 3D models that mimic the body's natural nerve connections (innervation). These bioengineered platforms aim to improve tissue regeneration and study tumor-nerve interactions for better human in vitro models.

Keywords:
3D in vitro modelsbioengineeringcancerinnervationtissue regeneration

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Innervation is crucial for tissue homeostasis, disease progression, and repair.
  • Current human in vitro models lack the complex innervation found in native tissues.
  • Emulating bioinstructive nerve influences is key to enhancing organotypic models.

Purpose of the Study:

  • To review strategies for creating innervated 3D tissue models.
  • To highlight advances in bioengineering living platforms for studying innervation.
  • To explore applications in tissue regeneration and tumor-nerve interactions.

Main Methods:

  • Review of current literature on generating innervated 3D models.
  • Analysis of bioengineering approaches for creating living platforms.
  • Examination of design blueprints for innervated tissue models.

Main Results:

  • Identification of latest strategies for mimicking native innervation patterns.
  • Highlighting recent advances in bioengineered living platforms.
  • Overview of challenges and potential biomedical breakthroughs.

Conclusions:

  • Innervated 3D models offer significant potential for advancing regenerative medicine.
  • These models can provide new insights into disease mechanisms, such as tumor-nerve interplay.
  • Further bioengineering efforts are needed to overcome current challenges and realize full biomedical potential.