[Biochemistry and metabolism of sugar substitutes]

The metabolisms of the sugar substitutes fructose, sorbitol and xylitol and their interdependence with the metabolism of glucose are demonstrated. The metabolic characteristics of these substitutes are discussed with regard to therapeutical utilization. Differences between oral and parenteral administration are shown and finally dosage guidelines for parenteral administration are established on the basis of the different metabolic effects depending on the administered dose.