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Advances in the application of temporal interference stimulation: a scoping review
Jiaojiao Peng1, Zhanhong Du2,3,4,5, Yi Piao6
1Department of Rahabilitation Medicine, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
Frontiers in Human Neuroscience
|June 16, 2025
Summary
Temporal Interference Stimulation (TIS) offers a noninvasive method to modulate deep brain activity, showing promise for treating neurological disorders. This review highlights TIS
Area of Science:
- Biomedical Engineering
- Neuroscience
- Neuromodulation
Background:
- Neuromodulation utilizes devices to modulate the nervous system for treating neurological and psychiatric disorders.
- Existing neuromodulation techniques face challenges with invasiveness and precision.
- There is a critical need for noninvasive deep brain stimulation methods.
Purpose of the Study:
- To review the research progress on the application of Temporal Interference Stimulation (TIS).
- To assess the efficacy of TIS in targeting deep brain regions.
- To identify future research directions for TIS applications.
Main Methods:
- A scoping review was conducted following Arksey and O'Malley's framework.
- Searches were performed in PubMed, Web of Science, and EMbase databases.
- Included studies were original research published in English until June 2024.
Main Results:
- Out of 708 identified studies, 33 were included in the review.
- The literature predominantly covers TIS development and application.
- All included studies confirmed TIS's ability to effectively target deep brain areas.
Conclusions:
- Temporal Interference Stimulation (TIS) can penetrate the cerebral cortex and modulate deep brain neural activity.
- TIS demonstrates potential for treating various central nervous system (CNS) disorders.
- Further research is recommended to elucidate TIS mechanisms and guide future applications.
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