Anaplastic Multiple Myeloma Presenting as Acute Liver Failure: A Case Report

Anaplastic multiple myeloma (AMM) is a rare, aggressive variant of multiple myeloma; liver involvement is even more exceedingly rare, with known poor response to conventional treatment. Diagnosis is challenging given the aggressive nature of the disease, with the majority of patients diagnosed postmortem. We present a 66-year-old female who presented with abnormal liver function tests and rapid progression to acute liver failure, with biopsy-proven AMM. To our knowledge, this is the second reported case of AMM of the liver.