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Innovations in Core-Shell Electrospinning: A Comprehensive Review in Recent Advances of Core-Shell Electrospun
B Akhila1, V Abhijith1, Mridula Sreedharan2,3
1School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala 686560, India.
ACS Biomaterials Science & Engineering
|June 16, 2025
Summary
Polylactic acid (PLA) nanofibers, especially core-shell structures, are key in biomedical engineering due to their sustainability and biocompatibility. Advanced electrospinning enables controlled drug release and enhanced performance for innovative medical devices.
Area of Science:
- Biomedical Engineering
- Materials Science
- Polymer Science
Background:
- Polylactic acid (PLA) nanofibers offer unique structural and functional properties for biomedical applications.
- PLA is a renewable, biodegradable, and biocompatible material meeting the demand for sustainable medical solutions.
- Its adjustable mechanical strength, degradation rate, and ability to form intricate architectures make it ideal for scaffolds, implants, and devices.
Purpose of the Study:
- To review fabrication techniques for coaxial electrospun PLA nanofibers.
- To highlight the benefits and potential applications of these advanced materials.
- To emphasize their role in innovative healthcare and sustainable biomedical practices.
Main Methods:
- Advanced electrospinning techniques for precise manipulation of PLA nanofibers.
- Fabrication of core-shell PLA nanofibers for enhanced properties.
- Encapsulation of bioactive compounds for controlled release.
Main Results:
- Core-shell PLA nanofibers exhibit enhanced mechanical performance, cellular adhesion, and proliferation.
- Electrospinning allows for structural integrity maintenance and controlled release of encapsulated compounds.
- PLA degradation products have a lower environmental impact compared to nondegradable polymers.
Conclusions:
- Coaxial electrospun PLA nanofibers are crucial for advanced biomedical applications.
- These materials offer significant advantages in terms of sustainability and performance.
- PLA nanofibers represent a promising direction for innovative healthcare products and sustainable biomedical practices.
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