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3D-Bioprinted Poly(lactic acid) Scaffolds Incorporated with Cerium Nitrate-Bound Silver Nanoparticles for Skin Tissue
Renuka Vijayaraghavan1,2, Vidyavathi Maruvajala3, Suresh Kumar Venkata Rayadurgam4
1Electrochemical Process Engineering, Council of Scientific and Industrial Research (CSIR)-Central Electrochemical Research Institute (CECRI), Karaikudi 630003, Tamil Nadu, India.
ACS Applied Bio Materials
|August 12, 2025
Summary
This study developed a novel 3D-printed poly(lactic acid) scaffold with silver nanoparticles and cerium nitrate. The scaffold significantly enhanced skin regeneration in animal models, offering a promising new treatment for chronic wounds.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Chronic full-thickness wounds present significant challenges in treatment and public health.
- Advanced wound healing strategies are crucial for improving patient outcomes and reducing healthcare burdens.
Purpose of the Study:
- To investigate the efficacy of a poly(lactic acid) (PLA)-based scaffold incorporating silver nanoparticles (AgNPs) and cerium nitrate (CN) for accelerated wound healing.
- To evaluate the physicochemical, antimicrobial, and cytocompatibility properties of the developed scaffold.
- To assess the scaffold's ability to promote skin regeneration in a preclinical model.
Main Methods:
- Synthesis and characterization of AgNPs modified with thioglycolic acid and bound to CN.
- Fabrication of PLA-based scaffolds using 3D printing (pneumatic extrusion).
- Evaluation of scaffold properties (physical, thermal, antimicrobial, degradation, cytocompatibility) and in vivo assessment of skin regeneration in rat models.
Main Results:
- The PLA/CN20-fAgNP scaffolds demonstrated favorable physicochemical and antimicrobial properties.
- Histological analysis confirmed that the scaffolds stimulated granulation tissue formation.
- Implantation in rat skin defects led to significantly improved skin regeneration, with regenerated tissue closely resembling healthy skin.
Conclusions:
- The developed 3D-printed PLA scaffold containing CN-bound AgNPs effectively promotes skin regeneration.
- This innovative biomaterial holds potential for improving the treatment of chronic full-thickness wounds.
- Further research can explore clinical applications for advanced wound management.
