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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Sep 19, 2025

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

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B₁-corrected breast T₁ mapping at ultralow field.

Sheng Shen^1,2, Neha Koonjoo^1,2, Stephen E Ogier^3,4

¹A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Magnetic Resonance in Medicine

|June 16, 2025

Summary

This summary is machine-generated.

This study introduces an efficient ultralow-field (ULF) MRI technique for accurate T1 mapping of breast tissue. The method corrects for B1 inhomogeneity, providing reliable T1 values without fat suppression.

Keywords:

T1 mapping breast MRI ultralow field variable flip angle method

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Area of Science:

Medical Imaging
Magnetic Resonance Imaging
Biophysics

Background:

Accurate T1 mapping is crucial for quantitative MRI in various tissues.
B1 field inhomogeneity poses a significant challenge for T1 mapping accuracy, especially in ultralow-field (ULF) MRI.
Developing bias-free T1 mapping methods is essential for reliable diagnostic applications.

Purpose of the Study:

To develop an efficient T1 mapping approach for ultralow-field (ULF) MRI that corrects for B1 inhomogeneity.
To determine the T1 values of breast tissues at 6.5 mT without fat suppression.
To validate the developed T1 mapping method in vitro and in vivo.

Main Methods:

A variable flip angle approach was employed for simultaneous T1 and B1 mapping.
B1 maps were used to correct T1 maps, improving accuracy.
The method was validated using copper sulphate phantoms and a breast phantom, followed by in vivo scans of healthy volunteers.

Main Results:

T1 map measurements in phantoms showed less than 13% deviation from reference T1 values.
For reference T1 values greater than 50 ms, the deviation was less than 6%.
In vivo T1 maps of breast tissue in healthy volunteers at 6.5 mT showed 25th to 75th percentiles ranging from 79 to 243 ms.

Conclusions:

The variable flip angle method is effective for simultaneous B1 and T1 mapping at ULF.
This approach enables efficient and accurate in vivo T1 mapping in ULF MRI.
The study provides reference T1 values for breast tissue at 6.5 mT.