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Terpyridine-Based Fluorescent Sensors: Investigating the Analytical Properties for Diverse Applications
Neelam Gupta1, Dheeraj Pandey1, Jyoti Pandey2
1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow, India.
Critical Reviews in Analytical Chemistry
|June 16, 2025
Summary
Terpyridine-based fluorescent probes offer versatile applications in biological and environmental sensing. This review highlights recent advancements in their design, synthesis, and diverse detection capabilities.
Area of Science:
- Supramolecular Chemistry
- Analytical Chemistry
- Materials Science
Background:
- Fluorescent probes are valuable tools in imaging and sensing due to their ease of use and cost-effectiveness.
- Terpyridine is a highly explored fluorescent core, amenable to functionalization for tailored sensor design.
- The tunable emission properties of terpyridine derivatives make them suitable for various detection applications.
Purpose of the Study:
- To review recent developments in terpyridine-based fluorescent sensors.
- To discuss the synthesis, sensing mechanisms, and photophysical properties of these probes.
- To highlight the diverse biological and non-biological applications of terpyridine sensors.
Main Methods:
- Compilation of recent literature on terpyridine-based sensors.
- Discussion of common synthetic strategies, including cross-coupling and central ring assembly.
- Analysis of sensing mechanisms, limits of detection, and photophysical parameters.
Main Results:
- Terpyridine sensors demonstrate broad applicability in environmental and biological sensing.
- Functionalization of the terpyridine core allows for tuning of emission wavelengths.
- Successful applications include detection of ions, nerve agents, biomolecules, and radioactive metals.
Conclusions:
- Terpyridine-based fluorescent probes represent a significant advancement in sensor technology.
- Their adaptable structure and tunable properties facilitate diverse applications.
- Continued research promises further innovation in terpyridine-based sensing platforms.
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