68 Ga-FAPI-04 PET Differentiates Benign From Malignant in a Patient With 18 F-FDG-Avid Colon Lesion

Lesions exhibiting heightened 18 F-FDG uptake in colorectal PET scans may be indicative of either benign or malignant processes, thus necessitating gastroscopic biopsy or pathologic assessment for diagnostic clarification. Herein, we reported intense 18 F-FDG uptake but negative 68 Ga-FAPI-04 PET uptake in a 65-year-old man with sigmoid colon tubular adenoma. This case underscores the utility of FAPI PET in preoperatively discerning between colorectal carcinoma and adenoma, potentially influencing treatment strategies.