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Published on: June 2, 2015
Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological
Kianna Nguyen1, Quang Tuan Che2, Quoc Huynh Nguyen2
1Medical Scientist Training Program, Mayo Clinic Alix School of Medicine & Mayo Clinic Graduate School of Biomedical Sciences, 200 1st St SW, Rochester, MN, USA. nguyen.kianna@mayo.edu.
Abstract:
Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.
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