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Heparinizable graft copolymers from chlorosulphonated polyethylene with poly(amido-amine) segments
Biomaterials
|July 1, 1985
Summary
Graft copolymers synthesized from polyethylene and poly(amido-amine)s show promise for biomedical devices. These heparinizable materials demonstrate good heparin complex stability, suitable for prosthetic applications.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Biomedical Engineering
Background:
- Development of advanced biomaterials is crucial for improving prosthetic devices.
- Graft copolymers offer tunable properties for specific biomedical applications.
- Heparinization is a key strategy to enhance the hemocompatibility of biomaterials.
Purpose of the Study:
- To synthesize and characterize novel graft copolymers (PES/PAA) for biomedical use.
- To evaluate the heparin-binding capacity and stability of these copolymers.
- To assess the suitability of these materials for prosthetic device construction.
Main Methods:
- Synthesis of three graft copolymers (PES/PAA) from chlorosulphonated polyethylene (PECS) and poly(amido-amine)s.
- Physical characterization of the synthesized graft copolymers.
- Biological evaluation of heparin adsorption and complex stability using activated Partial Thromboplastin Time (PTT) and Thrombin Time (TT) assays.
Main Results:
- Successful synthesis and characterization of three distinct PES/PAA graft copolymers.
- Demonstrated heparinizable properties suitable for biomedical applications.
- Favorable heparin adsorption and stable complex formation confirmed by PTT and TT tests.
Conclusions:
- The synthesized PES/PAA graft copolymers exhibit promising properties for biomedical prosthetic devices.
- These materials show good potential for hemocompatibility due to their heparin-binding capabilities.
- Further development could lead to advanced, safer prosthetic implants.