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Updated: Sep 19, 2025

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Thermolides D and E: Total Synthesis and Stereochemical Revision
Wenquan Peng1, Feipeng Han1, Junyang Liu2
1State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Abstract:
Using stereochemical insights and synthetic chemistry principles, we successfully achieved the total synthesis of two diastereomers of thermolide D, as well as the proposed structure of thermolide E. By comparing their NMR spectra and demonstrating coelution of the synthetic and natural products on a semipreparative HPLC column, we confirmed the correct structures of thermolides D and E. Additionally, the stereochemical approach used in this study provides a reliable framework for future structural determinations of fungal-derived polyketides.
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