Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

297
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
297
Seizures: Classification01:13

Seizures: Classification

620
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
620
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.0K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.0K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

685
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
685
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.7K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.7K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

463
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
463

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive mapping of Neurofibromin (NF1) expression in developing mouse brain.

bioRxiv : the preprint server for biology·2026
Same author

Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model of <i>PIK3CA</i>-Driven Intractable Epilepsy.

Frontiers in molecular neuroscience·2021
Same author

Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures.

Acta neuropathologica communications·2020
Same author

Laser Capture Micro-dissection (LCM) of Neonatal Mouse Forebrain for RNA Isolation.

Bio-protocol·2020
Same author

Early dorsomedial tissue interactions regulate gyrification of distal neocortex.

Nature communications·2019
Same author

PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice.

eLife·2019

Related Experiment Video

Updated: Sep 19, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

536

Developmental mechanisms underlying pediatric epilepsy.

Vishal Lolam1, Achira Roy1

  • 1Neurodevelopment Laboratory, Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, India.

Frontiers in Neurology
|June 18, 2025
PubMed
Summary
This summary is machine-generated.

Pediatric epilepsy presents complex challenges, with many children unresponsive to drugs. Understanding molecular pathways like PI3K-AKT-MTOR is crucial for developing targeted therapies to improve seizure control.

Keywords:
CiliaPI3K-AKT–MTOR pathwaySUDEPdrug resistanceepilepsy – abnormalitiesneurodevelopmentpediatric epilepsysleep and circadian rhythm

More Related Videos

Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

33.6K
Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
07:58

Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents

Published on: September 15, 2011

9.4K

Related Experiment Videos

Last Updated: Sep 19, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

536
Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

33.6K
Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents
07:58

Preparing Undercut Model of Posttraumatic Epileptogenesis in Rodents

Published on: September 15, 2011

9.4K

Area of Science:

  • Neuroscience
  • Pediatric Neurology
  • Molecular Biology

Background:

  • Pediatric epilepsy is a significant challenge due to variable onset, complex causes, and treatment resistance in ~30% of cases.
  • Drug-resistant epilepsy often necessitates surgery, but post-operative foci development leads to recurrent surgeries and reduced quality of life.
  • Understanding the underlying molecular mechanisms is critical for developing targeted therapies.

Purpose of the Study:

  • To review the developmental mechanisms of pediatric epilepsy.
  • To highlight the PI3K-AKT-MTOR pathway as a central node in diverse epilepsy mechanisms.
  • To explore potential molecular targets for novel, non-invasive therapies.

Main Methods:

  • Comprehensive literature review of pediatric epilepsy mechanisms.
  • Analysis of genetic and environmental factors contributing to epilepsy.
  • Focus on the role of the PI3K-AKT-MTOR pathway in disease pathogenesis.

Main Results:

  • Identified diverse genetic and environmental factors implicated in pediatric epilepsy.
  • Highlighted the PI3K-AKT-MTOR pathway as a key integrator of various epilepsy mechanisms.
  • Emphasized the shift from single-channel dysfunction to complex multifactorial etiology.

Conclusions:

  • Mechanistic understanding of pediatric epilepsy is evolving beyond ion channel dysfunction.
  • The PI3K-AKT-MTOR pathway offers a promising target for developing novel therapeutic strategies.
  • Further research into molecular pathways is essential for advancing non-invasive treatments for pediatric epilepsy.