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Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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Antidotes01:17

Antidotes

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Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
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Types of Toxins01:36

Types of Toxins

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

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Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
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Interdisciplinary Care: The Health Care Team-II01:18

Interdisciplinary Care: The Health Care Team-II

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An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care. Here are a few more healthcare professionals.
Physical Therapist
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Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

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Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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The Value of Medical Toxicologists.

Paul M Wax1, Tracy M Kolian1, Anthony F Pizon2,3

  • 1American College of Medical Toxicology (ACMT), Phoenix, AZ, USA.

Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology
|June 19, 2025
PubMed
Summary

Medical toxicologists are crucial for treating poisonings and the opioid crisis, improving patient outcomes and public health. Their value in healthcare systems needs greater recognition for better patient care and prevention strategies.

Keywords:
Medical ToxicologistsToxicology

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Area of Science:

  • Public Health
  • Medical Toxicology
  • Healthcare Systems

Background:

  • Poisoning is a significant public health concern and a leading cause of injury-related death in the US.
  • Medical toxicologists are specialized physicians vital in managing poisoning cases, including drug overdoses and exposures.
  • The financial and societal impact of poisonings, particularly opioid-related, is substantial.

Purpose of the Study:

  • To articulate and demonstrate the value of medical toxicologists in improving patient outcomes.
  • To highlight the positive impact of medical toxicology on population health and healthcare systems.
  • To advocate for the medical toxicology profession in a value-based care environment.

Main Methods:

  • Reviewing the roles and contributions of medical toxicologists in patient care and public health.
  • Analyzing the impact of medical toxicologists on managing poisoning and substance use disorders.
  • Modeling the value proposition of medical toxicology based on established efforts in infectious diseases.

Main Results:

  • Medical toxicologists significantly contribute to patient care, population health, and healthcare system improvements.
  • Their expertise is critical in addressing the opioid epidemic and broader substance use disorders.
  • There is a recognized need to better communicate the value provided by medical toxicologists to stakeholders.

Conclusions:

  • Medical toxicologists play an indispensable role in mitigating the impact of poisonings and addiction.
  • Enhanced recognition and advocacy are necessary for medical toxicologists to thrive in a value-based care market.
  • Demonstrating the value of medical toxicology is essential for optimizing patient outcomes and public health initiatives.