Related Experiment Video
Updated: Sep 18, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A Dataset of Medical Questions Paired with Automatically Generated Answers and Evidence-supported References
Deepak Gupta1, Davis Bartels2, Dina Demner-Fushman2
1National Library of Medicine, National Institutes of Health, HHS, Bethesda, MD, USA. deepak.gupta@nih.gov.
Abstract:
New Large Language Models (LLM)-based approaches to medical Question Answering show unprecedented improvements in the fluency, grammaticality, and other qualities of the generated answers. However, the systems occasionally produce coherent, topically relevant, and plausible answers that are not based on facts and may be misleading and even harmful. New types of datasets are needed to evaluate the truthfulness of generated answers and develop reliable approaches for detecting answers that are not supported by evidence. The MedAESQA (Medical Attributable and Evidence Supported Question Answering) dataset presented in this work is designed for developing, fine-tuning, and evaluating language generation models for their ability to attribute or support the stated facts by linking the statements to the relevant passages of reliable sources. The dataset comprises 40 naturally occurring aggregated deidentified questions. Each question has 30 human and LLM-generated answers in which each statement is linked to a scientific abstract that supports it. The dataset provides manual judgments on the accuracy of the statements and the relevancy of the scientific papers.
Related Concept Videos
Data Collection I
The Availability Heuristic
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Statistical Software for Data Analysis and Clinical Trials
Hazard Ratio
For example, in a clinical trial...
Nursing Clinical Information System
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:

