[Drug-induced systemic lupus erythematosus]

This case report describes a 63-year-old female patient with hypertension who developed drug-induced systemic lupus erythematosus (SLE) after hospitalization for syncope and severe hyponatraemia. Her complex medication regimen, including antihypertensives and proton pump-inhibitors, complicated the identification of a specific trigger. Positive anti-histone antibodies supported the diagnosis. Treatment with immunosuppressants and discontinuation of suspected drugs led to remission. This case highlights the importance of recognizing drug triggers in elderly patients with extensive medication use.