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Membranous Nephropathy and Papillary Thyroid Cancer: A Case Report
David Yogev1,2,3, Arad Dotan2,3, Ohad Bitan2,3
1Department of Otolaryngology Head and Neck Surgery, Sheba Medical Center, Ramat Gan, Israel.
The Laryngoscope
|June 20, 2025
Summary
A rare association between membranous nephropathy and papillary thyroid carcinoma was observed. Surgical removal of the thyroid tumor improved kidney function, suggesting a paraneoplastic link.
Area of Science:
- Nephrology
- Oncology
- Endocrinology
Background:
- Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults.
- Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer.
- The association between MN and PTC is rare, with limited documented cases.
Observation:
- A 66-year-old female presented with progressive renal dysfunction.
- Diagnosis of MN was confirmed with negative phospholipase A2 receptor (PLA2R) staining.
- Imaging revealed an incidental finding of papillary thyroid carcinoma.
Findings:
- Total thyroidectomy resulted in significant clinical improvement of renal dysfunction.
- This suggests a potential paraneoplastic mechanism linking MN and PTC.
- The absence of PLA2R staining in MN may indicate alternative underlying causes.
Implications:
- Highlights the importance of oncologic screening in patients diagnosed with MN, particularly those with atypical presentations.
- Suggests a potential paraneoplastic relationship between PTC and PLA2R-negative MN.
- Emphasizes the need for further research into the pathophysiological mechanisms connecting autoimmune kidney diseases and thyroid malignancies.
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