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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Related Experiment Video

Updated: Sep 18, 2025

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[BASIC is an instrument for dementia assessment].

Kasper Jørgensen1, Thomas Rune Nielsen1,2, Ann Nielsen1

  • 1Nationalt Videnscenter for Demens, Afdeling for Hjerne- og Nervesygdomme, Neurocentret, Københavns Universitetshospital - Rigshospitalet.

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|June 20, 2025
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Summary

The Brief Assessment Schedule and Checklist (BASIC) is a validated tool for identifying cognitive impairment and dementia. It demonstrates comparable or superior accuracy to existing tests, regardless of education, age, gender, or ethnicity.

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Area of Science:

  • Gerontology and Cognitive Neurology
  • Diagnostic Accuracy and Clinical Assessment Tools

Context:

  • Development and validation of the Brief Assessment Schedule and Checklist (BASIC) for cognitive impairment and dementia.
  • Evaluation in diverse settings including memory clinics and general practice across European countries.

Purpose:

  • To introduce BASIC as a novel, efficient case-finding instrument for cognitive impairment and dementia.
  • To compare the diagnostic accuracy of BASIC against established, time-intensive cognitive tests.
  • To assess the influence of demographic factors (education, age, gender, ethnicity) on BASIC's performance.

Summary:

  • BASIC exhibits diagnostic accuracy for dementia and mild cognitive impairment that is equivalent or superior to current lengthy cognitive tests.
  • A significant correlation exists between BASIC scores and the severity of cognitive impairment.
  • BASIC's accuracy is not significantly affected by educational background, age, or gender, and is consistent across native Europeans and immigrants.

Impact:

  • BASIC offers a more time-efficient and accurate method for early detection of cognitive impairment and dementia in clinical practice.
  • Its robustness across diverse demographic groups, including immigrants, enhances its utility in multicultural healthcare settings.
  • Facilitates broader and earlier screening, potentially improving patient outcomes through timely intervention.