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Related Experiment Video

Updated: Sep 18, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Infectious Keratitis After Corneal Cross-Linking: A Retrospective Case Series.

Bjarne Løberg Thorbjørnsen1,2, Marthe Andrea Velle-Skretteberg1,2, Andreas Thorsrud1

  • 1Department of Ophthalmology, Oslo University Hospital, Oslo, Norway; and.

Cornea
|June 20, 2025
PubMed
Summary
This summary is machine-generated.

Infectious keratitis after corneal cross-linking (CXL) for corneal ectasia is rare, with a low incidence of 0.3% in this study. This finding indicates a low risk for patients undergoing CXL treatment.

Keywords:
CXLcorneal cross-linkingcorneal ectasiakeratitiskeratoconus

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Infectious Diseases

Background:

  • Corneal ectasia comprises a group of progressive thinning disorders of the cornea.
  • Corneal cross-linking (CXL) is a standard treatment for corneal ectasia.
  • Infectious keratitis is a potential complication following ocular procedures.

Purpose of the Study:

  • To evaluate the incidence and risk of infectious keratitis after corneal cross-linking (CXL) in patients with corneal ectasia.
  • To compare the risk of infectious keratitis in this cohort with existing literature.

Main Methods:

  • Retrospective case series of patients undergoing CXL for corneal ectasia at Oslo University Hospital (2007-2020).
  • Review of medical records for keratitis diagnosis within 6 months post-CXL.
  • Literature review of studies reporting infectious keratitis risk after CXL.

Main Results:

  • 1809 CXL procedures were performed; 11 cases (0.6%) had a keratitis code.
  • 5 cases (0.3%) were identified as procedure-related infectious keratitis.
  • Microbiological agents included Staphylococcus aureus and Acanthamoeba; incidence is comparable to literature (0%-2.6%).

Conclusions:

  • Corneal cross-linking (CXL) for corneal ectasia has a low incidence of infectious keratitis.
  • The risk of procedure-related infectious keratitis following CXL is low.
  • Findings support the safety profile of CXL in managing corneal ectasia.