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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Visible Light-Driven Deracemization of Cyclic Sulfonamides by Quinuclidine and Chiral Arylthiol Catalysis
Lei Dai1, Jing Wang1, Chaoren Shen1
1State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
Abstract:
A photocatalytic system comprising an achiral tertiary amine and a chiral C2-symmetric arylthiol was developed for the deracemization of various cyclic sulfonamides. This protocol exhibited high yields, good to excellent enantioselectivity, and broad substrate scope. The resulting products can be readily transformed into diverse diarylmethylamines, presenting a viable alternative to metal-catalyzed asymmetric methods. The reaction pathway involving a relay of non-enantioselective hydrogen-atom abstraction (HAA) and enantioselective hydrogen-atom delivery (HAD).
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