Related Experiment Video
Updated: Sep 18, 2025
Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
Published on: May 17, 2019
Chronic Oral Complications of Oral Cancer Therapy
Madison E Richards1, Michael T Brennan2
1Department of Oral Medicine /Oral & Maxillofacial Surgery, Atrium Health Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA.
Abstract:
Head and neck cancer (HNC) patients are uniquely susceptible to adverse oral health outcomes following head and neck radiation therapy (RT). Various risk factors for these oral health outcomes post-RT were identified in the OraRad study, which followed HNC patients from pre-RT to 2 y post-RT. Chronic oral complications include hyposalivation, trismus, dental caries, periodontal disease, tooth loss, exposed bone, and osteoradionecrosis of the jaw. Results from OraRad provide a framework for oral health care providers both in preparing patients for RT and in managing sequelae of RT for best outcomes for the HNC patient population.
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