Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prodrugs01:30

Prodrugs

3.1K
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
3.1K
Drug Discovery: Overview01:26

Drug Discovery: Overview

8.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design and Evaluation of Conformationally Locked Indole-Carboxylic Acids as Selective THRβ Agonists against MASH.

Journal of medicinal chemistry·2026
Same author

Discharge-Induced Enhancement of the Oxygen Evolution Reaction.

Angewandte Chemie (International ed. in English)·2021
Same author

Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Pterygium by MeRIP Sequencing.

Frontiers in cell and developmental biology·2021
Same author

Development and validation of a novel metabolic signature for predicting prognosis in patients with laryngeal cancer.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2021
Same author

17<i>β</i>-Estradiol Attenuates LPS-Induced Macrophage Inflammation In Vitro and Sepsis-Induced Vascular Inflammation In Vivo by Upregulating miR-29a-5p Expression.

Mediators of inflammation·2021
Same author

Engineering Active Micro and Nanomotors.

Micromachines·2021
Same journal

Impact of an Artificial Albumin Corona on Surface Charge-Driven Nano-Bio Interactions and Cytotoxicity of Silver Nanoparticles.

ACS omega·2026
Same journal

Structural and Functional Disruption of Thiopurine S‑Methyltransferase by the A80P Variant: A Simulation and Genotyping Study.

ACS omega·2026
Same journal

CRISPR/Cas12a2-Mediated Ultrasensitive Assay for Rapid Detection of H1N1 Influenza Virus RNA.

ACS omega·2026
Same journal

Photocatalytic Treatment of Real Sugar Industry Wastewater Using Lignocellulosic Biomass-Derived Hydrochar/g-CN.

ACS omega·2026
Same journal

Electrochemical Dopamine Biosensor Based on Plant-Derived Peroxidase Immobilized on Titanate Nanowires.

ACS omega·2026
Same journal

Revealing the Effects of Process Parameters on Structural, Thermal, Mechanical, Biodegradation, and Biocompatibility Properties on the Electrospinning of Poly(vinyl alcohol)/Microbial Inulin Nanofibers.

ACS omega·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

10.1K

Prodrug Strategy for PROTACs: High Efficiency and Low Toxicity.

Yuqing Li1, Yongcheng Guo1, Simin Ma1

  • 1School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China.

ACS Omega
|June 23, 2025
PubMed
Summary
This summary is machine-generated.

Proteolysis-targeting chimeras (PROTACs) offer novel therapeutic strategies for undruggable targets. PROTAC prodrugs enhance safety and efficacy by enabling targeted protein degradation, addressing current limitations.

More Related Videos

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.4K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.2K

Related Experiment Videos

Last Updated: Sep 18, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

10.1K
Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.4K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.2K

Area of Science:

  • Biochemistry
  • Pharmacology
  • Drug Discovery

Background:

  • Proteolysis-targeting chimeras (PROTACs) utilize endogenous E3 ligases for targeted protein degradation.
  • PROTACs offer a promising approach for
  • PROTACs have shown potential in treating diseases like cancer, expanding drug development avenues.

Purpose of the Study:

  • To review activation methods and optimization strategies for PROTACs.
  • To discuss PROTAC prodrugs as a strategy to overcome limitations in clinical implementation.
  • To explore PROTAC delivery systems for improved druggability.

Main Methods:

  • Review of current literature on PROTAC technology.
  • Analysis of PROTAC prodrug activation mechanisms (light, enzymes, immune components).
  • Examination of various PROTAC delivery systems (polymers, conjugates, liposomes, albumin).

Main Results:

  • PROTACs offer a novel mechanism for targeted protein degradation, addressing previously undruggable targets.
  • PROTAC prodrugs enable spatiotemporally controlled protein degradation, mitigating systemic toxicity and improving bioavailability.
  • Diverse delivery systems are being developed to enhance PROTAC druggability and therapeutic potential.

Conclusions:

  • PROTAC prodrugs represent a significant advancement in targeted protein degradation therapy.
  • Optimized activation and delivery strategies are crucial for the successful clinical translation of PROTACs.
  • Further research into PROTAC prodrugs and delivery systems will expand their therapeutic applications.