Related Experiment Video
Updated: Sep 18, 2025

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
Published on: April 1, 2013
Microwave-Assisted Intramolecular Dehydrogenative Coupling Reaction: Access to γ-Carboline Derivatives
Lifeng Jiang1, Xiang Zhou1, Furen Zhang1
1School of Chemistry and Chemical Engineering, Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing 312000, Zhejiang Province, P. R. China.
None:
A microwave-assisted intramolecular dehydrogenative coupling reaction for the construction of novel γ-carbolines was established. Following Pd(II)/Cu(II)-catalyzed C-H activation, intramolecular cyclization provided γ-carbinone derivatives with various substituents in 57-85% yield. The rapid synthesis of γ-carbolines and wide functional group tolerance are among the advantages of this microwave-assisted approach.
Related Concept Videos
Alkenes via Reductive Coupling of Aldehydes or Ketones: McMurry Reaction
Cycloaddition Reactions: Overview
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
Cycloaddition Reactions: MO Requirements for Thermal Activation

