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Updated: Sep 18, 2025
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
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Association between Exposure to Statin Choice and Adherence to Statins: An Observational Cohort Study
Kathryn A Martinez1, Victor M Montori2, Fatima Rodriguez3
1Cleveland Clinic Center for Value-Based Care Research, Cleveland, OH, USA.
Summary
Clinician use of Statin Choice, an electronic health record tool, significantly increased statin prescriptions and adherence. This tool also led to a reduction in low-density lipoprotein cholesterol levels over one year.
Area of Science:
- Cardiology
- Health Informatics
- Pharmacology
Background:
- Statin Choice is a shared decision-making tool integrated into electronic health records.
- Previous studies showed modest associations between Statin Choice and statin adherence using patient-reported data.
Purpose of the Study:
- To examine the association between using Statin Choice and statin prescriptions, primary adherence (prescription fills), and secondary adherence (statin use at 12 months).
Main Methods:
- An observational cohort study was conducted at the Cleveland Clinic Health System.
- 17,001 statin-naïve adults aged 40-75 with a ≥5% 10-year ASCVD risk were included.
- Mixed-effects logistic regression analyzed the odds of statin prescription and adherence based on Statin Choice use.
Main Results:
- Patients shown Statin Choice had 9.04 times higher odds of being prescribed a statin.
- Statin Choice use was associated with 5.75 times higher odds of primary adherence.
- Statin Choice use was linked to a 12 mg/dL reduction in LDL cholesterol at 12 months.
Conclusions:
- Statin Choice use strongly correlates with increased statin prescriptions and fills.
- The tool showed a weak association with statin adherence up to one year.
- A randomized trial is recommended to confirm causality.
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