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Deep brain stimulation for refractory epilepsy: A meta-analysis of stimulation parameters
Pooya Vahedi1, Shahab Lotfinia2, Alireza Zali3
1School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical Neurology and Neurosurgery
|June 24, 2025
Summary
Deep brain stimulation (DBS) shows promise for drug-resistant epilepsy. Tailoring DBS parameters like voltage and frequency is crucial for improving patient outcomes in refractory epilepsy cases.
Area of Science:
- Neurology
- Neurosurgery
- Medical Devices
Background:
- Epilepsy impacts 50 million globally, with 30% showing resistance to antiepileptic drugs.
- Neuromodulation, specifically deep brain stimulation (DBS), is vital for managing refractory epilepsy.
Purpose of the Study:
- To conduct a meta-analysis evaluating the efficacy of deep brain stimulation (DBS) in patients with refractory epilepsy.
- To identify key factors influencing treatment success in DBS for epilepsy management.
Main Methods:
- Systematic literature search of PubMed, Scopus, and Web of Science databases following PRISMA guidelines.
- Meta-analysis of 49 studies including 682 patients with refractory epilepsy who underwent DBS.
- Analysis of various DBS interventions targeting brain regions like the thalamus and hypothalamus with diverse stimulation parameters.
Main Results:
- DBS interventions targeting specific brain regions were analyzed.
- Diverse stimulation parameters (voltage, frequency, type) were investigated.
- These parameters significantly influenced treatment success, though moderate variability existed across studies.
Conclusions:
- Tailored deep brain stimulation (DBS) parameters are essential for optimizing outcomes in drug-resistant epilepsy.
- Deep brain stimulation (DBS) represents a promising therapeutic strategy for patients with refractory epilepsy.
