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Updated: Sep 18, 2025

Modeling the Size Spectrum for Macroinvertebrates and Fishes in Stream Ecosystems
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There's Always a Bigger Fish.

Nicolas Kitic1, Adélaïde Toutee1, Isabelle Audo2,3

  • 1Department of Ophthalmology, Sorbonne University, Pitiè-Salpêtrière Hospital, Paris, France.

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|June 24, 2025
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Summary
This summary is machine-generated.

Cancer-associated retinopathy (CAR) can cause sudden vision loss and may precede cancer diagnosis. This case highlights a patient with tongue carcinoma who developed CAR due to a metastatic uterine neuroendocrine carcinoma.

Keywords:
Auto-immune retinopathycancer-associated retinopathyneuro-endocrine tumortongue carcinomauterine carcinoma

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Area of Science:

  • Ophthalmology
  • Oncology
  • Neuroscience

Background:

  • Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome affecting the retina.
  • It is often associated with various cancers, leading to progressive vision loss.

Observation:

  • A 72-year-old female with tongue carcinoma presented with acute bilateral vision loss.
  • Ophthalmological examination revealed rapid outer retinal atrophy.
  • Systemic work-up unexpectedly identified metastatic uterine neuroendocrine carcinoma.

Findings:

  • The patient experienced severe vision loss to light perception within days.
  • Standard treatments including corticosteroids, plasmapheresis, and chemotherapy did not restore vision.
  • CAR syndrome can manifest before the primary tumor is diagnosed.

Implications:

  • This case underscores the importance of a comprehensive medical history and diagnostic work-up for CAR syndrome.
  • Early identification of the underlying malignancy is crucial, even in patients with existing cancer diagnoses.
  • CAR syndrome necessitates a broad oncological investigation to uncover the primary tumor source.