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Updated: Sep 18, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Unlocking Cellular Memory and Gene Regulatory Networks: Pioneering the Future of Therapeutic Innovations
Md Sorique Aziz Momin1, Jhuma Bhadra2, Debmalya Bhunia3
1School of Physics and Astronomy, College of Science, Rochester Institute of Technology, Rochester, NY 14623, USA.
Abstract:
Cellular memory is the competence of cells to preserve information from past experiences and respond aptly. This memory is maintained and controlled by gene regulatory networks (GRNs). GRNs are crucial for understanding why some cells are resistant to treatment, particularly for cancer. In our study, we created a new mathematical model to understand how "noise" affects cellular memory in GRNs, focusing on a "double positive feedback loop". Our theoretical perspective article equipped with mathematical modeling exhibits how noise and feedback loops interact in GRNs. It also proposes a potential theoretical avenue for future therapy. By targeting the mechanisms that maintain drug resistance in cells, we aim to develop therapies that can restore the sensitivity of cancer cells to treatment.
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