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Related Concept Videos

Prodrugs01:30

Prodrugs

Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...

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Related Experiment Video

Updated: Jun 16, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Advanced Peptide Modifications for Superior Therapeutics.

Jhuma Bhadra1, Nayan De2, Md Sorique Aziz Momin3

  • 1School of Applied & Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Kolkata 700032, India.

Biochemistry
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

Therapeutic peptides offer a promising bridge between small molecules and biologics, excelling in specificity and safety. Advances in peptide drug development are accelerating their clinical translation across diverse diseases.

Keywords:
drug deliverynoncanonical amino acids (ncAAs)peptide therapeuticspeptide-drug conjugatephage displaysolid-phase peptide synthesis

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Last Updated: Jun 16, 2026

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Published on: March 8, 2018

Area of Science:

  • Biochemistry
  • Pharmacology
  • Drug Discovery

Background:

  • Peptides represent a unique therapeutic class, bridging small molecules and biologics.
  • They offer high specificity, favorable safety profiles, and diverse biological functions.
  • Peptide therapeutics show promise in metabolic disorders, oncology, infectious diseases, and pain management.

Purpose of the Study:

  • To review recent advancements in peptide therapeutics.
  • To discuss strategies for peptide design, modification, and drug delivery.
  • To highlight applications in various diseases and future clinical translation challenges.

Main Methods:

  • Review of recent progress in peptide therapeutics.
  • Analysis of design and modification strategies, including noncanonical amino acids.
  • Examination of applications in drug delivery systems and peptide-drug conjugates.

Main Results:

  • Peptide drug development is accelerated by advances in phage display, chemical synthesis, and drug delivery.
  • Therapeutic peptides are being explored for diabetes, cancer, and antimicrobial/antiviral applications.
  • Emerging opportunities and challenges for clinical translation are identified.

Conclusions:

  • Peptide therapeutics offer significant advantages and are rapidly advancing.
  • Continued innovation in design, delivery, and conjugation is key for clinical success.
  • Peptides hold substantial potential for treating a wide range of diseases.