Related Experiment Video
Updated: Sep 18, 2025
05:31
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
10.5K
SARS-CoV-2 in Asthmatic Children: Same Consequences in Different Endotypes?
Alice Bosco1, Vassilios Fanos1, Serena Bosone1
1Neonatal Intensive Care Unit, AOU Cagliari, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.
Metabolites
|June 25, 2025
Summary
Asthmatic children surprisingly had milder COVID-19, but obesity is a concern. Metabolomics can identify vulnerable children and guide personalized pandemic treatments for asthma and obesity.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Metabolomics
Background:
- Asthmatic children showed unexpected mildness during SARS-CoV-2 pandemic.
- Obesity is a comorbidity in difficult asthma and a risk factor for severe COVID-19.
- Childhood obesity has increased, exacerbating pandemic concerns.
Purpose of the Study:
- To explore asthma endotypes and their shared immunometabolic pathways with COVID-19.
- To highlight the role of metabolomics in understanding these complex interactions.
- To identify potential biomarkers for risk stratification and therapeutic targets.
Main Methods:
- Review of asthma endotypes and immunometabolic pathways.
- Focus on high-throughput technologies, particularly metabolomics.
- Analysis of minimally invasive sampling, including exhaled breath condensate (EBC).
Main Results:
- Asthma and COVID-19 share complex immunometabolic pathways.
- Metabolomics offers precise, unbiased evidence for endotyping.
- Identification of potential biomarkers for vulnerable individuals.
Conclusions:
- Metabolomics can aid in accurate risk stratification during viral pandemics.
- Personalized interventions are crucial, especially with comorbidities like obesity.
- Metabolomics may reveal new molecular and therapeutic targets for asthma and COVID-19.
Related Concept Videos
01:26Asthma-II: Pathophysiology and Classification
2.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.9K
01:20Asthma: Pathogenesis and Management
618
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
618
01:24Asthma-III: Symptoms and Complications
2.7K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.7K
01:30Asthma-IV: Diagnostic and Management
2.6K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.6K
01:29Asthma-I: Introduction
2.8K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.8K
01:20COPD: Pathogenesis and Clinical Features
540
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
540