Dual-Function Fluorescent Probes for Neuronal Trans-Differentiation: A Promising Therapeutic Strategy in
Pratikshya Paudel1, Prabir Kumar Gharai2
1Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Abstract:
Neurodegenerative diseases cause progressive neuronal loss, with current treatments offering only limited symptomatic relief. To overcome this, various strategies are being explored. One promising approach involves converting human mesenchymal stem cells (hMSCs) into functional neurons using a small molecule, alongside the use of fluorescent probes for real-time imaging. Therefore, developing a promising single compound that combines both differentiation-inducing and imaging capabilities without relying on growth factors could significantly advance neuroregenerative therapies and diagnostic strategies in neuroscience research.
