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High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
Can Oxytocin Neuropeptide Promote Human Mesenchymal Stem Cells to Neuron Conversion?: A Novel Approach in Future
Pratikshya Paudel1, Rahul Pandit Kumarchinchole1, Prabir Kumar Gharai2
1Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Abstract:
Neurodegenerative diseases are characterized by progressive neuronal loss, for which human mesenchymal stem cell (hMSC)-based therapies present a promising regenerative approach. Oxytocin, a neuropeptide known for its neuroprotective and anti-inflammatory properties, has been reported to inhibit GSK-3β in certain models. Given the established role of GSK-3β inhibition in promoting neurogenesis via Wnt/β-catenin signaling, this viewpoint explores the hypothesis that oxytocin could serve as a peptide-based cue to drive neuronal differentiation of MSCs. Consequently, developing effective therapy by emulating the oxytocin sequence could substantially enhance neuroregenerative treatments in neuroregenerative research.
