Cell-Penetrating Peptoids: A Dual Functional Strategy for Upcoming Neuroregeneration Application

Effective therapies for neurological conditions are a significant challenge since limited capacity of neurons for regeneration affects neuronal recovery. Despite their ineffective in vivo direct development into neurons, human mesenchymal stem cells (hMSCs) exhibit therapeutic promise through immunological regulation, neuroprotection, and improvement of endogenous repair. A promising strategy is to convert hMSCs into functional neurons using peptoids that also possess cell-penetrating abilities. Therefore, developing cell-penetrating peptoids that combine effective cellular uptake with neural differentiation induction could significantly progress neuroscience research and neuroregenerative treatments.