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Hallmarks of stem cell aging.

Thomas A Rando1, Anne Brunet2, Margaret A Goodell3

  • 1Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Biology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.

Cell Stem Cell
|June 25, 2025
PubMed
Summary
This summary is machine-generated.

Aging somatic stem cells lose function, impacting tissue repair. This review details five key aging features in stem cells, offering insights into aging and potential rejuvenation therapies to extend health span.

Keywords:
agingdifferentiationhematopoietic stem cellsheterogeneitymuscle stem cellsneural stem cellsquiescencestem cells

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Area of Science:

  • Gerontology and Stem Cell Biology
  • Molecular and Cellular Biology
  • Regenerative Medicine

Background:

  • Somatic stem cells are crucial for tissue homeostasis and regeneration throughout life.
  • Despite some protection, stem cells are susceptible to intrinsic and extrinsic aging factors.
  • Progressive loss of stem cell function contributes to organismal aging and reduced regenerative capacity.

Purpose of the Study:

  • To review and delineate the five cardinal features characterizing aged somatic stem cells.
  • To examine how these age-related alterations lead to functional decline in various stem cell populations.
  • To identify potential therapeutic targets for stem cell rejuvenation and enhanced tissue health span.

Main Methods:

  • Literature review of studies on somatic stem cell aging.
  • Analysis of established hallmarks of aging in different stem cell compartments.
  • Synthesis of findings to connect cellular aging features with functional decline.

Main Results:

  • Identification of five key features defining aged stem cells.
  • Demonstration of how these features contribute to impaired tissue homeostasis and regeneration.
  • Highlighting the vulnerability of stem cells to aging stressors.

Conclusions:

  • Aged stem cells exhibit distinct characteristics that impair their function.
  • Understanding these hallmarks provides insights into the aging process.
  • Targeting these features offers a promising avenue for therapeutic interventions to promote longevity and health span.