Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review

Conventional endodontic treatment has several disadvantages, which lead to the introduction of regenerative endodontic procedures aiming to maintain tooth vitality. Platelet concentrates possess relevant biological properties, and their application has been explored in various endodontic procedures. The aim of this scoping review is to identify the applications of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in endodontics. To identify and map the types of studies, the protocols for obtaining PRF/PRP, the most productive authors, and the journals where most articles were published on this topic until 2023. A literature search was performed in four databases (Medline, Embase, Cochrane Library, and Web of Science) until 20 December 2023. From the included articles, the following information was extracted: first author and publication year, endodontic procedure, platelet concentrate used, type of study, and journal of publication. A sampling methodology was adopted, and the five most recent articles for each procedure were used for additional information extraction: sample size and characteristics, pulp and periapical diagnosis, study protocol, platelet substrate and protocol for its obtention, treatment outcome, and follow-up. After selection, 412 articles were included. As for the type of endodontic procedure, regeneration procedures of immature teeth were the most reported, followed by apical surgery and pulpotomy and pulp protection. It was concluded that PRF is the most reported platelet concentrate. Regenerative procedures in immature teeth are the most described endodontic procedure. The success rate of PRF and PRP use is comparable to or even higher than that of conventional procedures and materials. However, there is significant heterogeneity in the protocols used for obtaining PRF and PRP and their clinical application.