Screening for developmental delay at 18 months using the Infant Toddler Checklist: A validation study
Cornelia M Borkhoff1,2, Haris Imsirovic3, Imaan Bayoumi3,4
1Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Plos One
|June 26, 2025
Summary
The Infant Toddler Checklist (ITC) shows high specificity for detecting developmental concerns in toddlers. While it has low sensitivity, a positive ITC score predicts increased healthcare use, including neurodevelopmental consultations.
Area of Science:
- Pediatric Health
- Developmental Pediatrics
- Health Services Research
Background:
- Early detection of developmental concerns is crucial for timely intervention.
- The Infant Toddler Checklist (ITC) is a potential tool for screening at the 18-month well-child visit.
- Understanding the predictive validity and healthcare utilization associated with positive ITC screening is important.
Purpose of the Study:
- To examine the predictive validity of the Infant Toddler Checklist (ITC).
- To assess the association between positive ITC screening and subsequent healthcare utilization (HCU).
Main Methods:
- Prospective cohort study of 1460 children at their 18-month primary care visit.
- Parents completed the ITC; health administrative databases tracked healthcare utilization.
- Neurodevelopmental consultation was the primary outcome measure.
Main Results:
- 11% of children screened ITC positive; 2.6% received a neurodevelopmental consultation by age 8.
- The ITC demonstrated 40% sensitivity and 90% specificity for detecting neurodevelopmental consultation.
- A positive ITC was significantly associated with increased rates of 6 of 7 HCU types, including neurodevelopmental consultation (aRR 2.78).
Conclusions:
- The ITC exhibits high specificity and a low false positive rate, minimizing unnecessary anxiety and resource use for most children.
- The low sensitivity of the ITC underscores the necessity of continued developmental surveillance.
- Findings suggest the ITC can be a valuable screening tool when complemented by ongoing developmental monitoring.
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