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Updated: Jul 31, 2026

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Primary Dedifferentiated Liposarcoma of the Duodenum with Intestinal Bleeding: A Case Report and Literature Review
Yuki Noguchi1, Kazumichi Abe2, Hidemichi Imamura1
1Department of Gastroenterology, Ohta General Hospital Foundation Ohta Nishinouchi Hospital, Japan.
Abstract:
A 51-year-old woman presented with syncope and gastrointestinal bleeding. Imaging revealed a 7-cm duodenal mass with mesenteric and pancreatic involvement. An endoscopic biopsy confirmed dedifferentiated liposarcoma. She received palliative radiotherapy to control bleeding, followed by eribulin-based chemotherapy, which temporarily shrank the tumor and allowed discontinuation of parenteral nutrition. Additional radiotherapy did not prevent disease progression, and chemotherapy was discontinued. The patient died nine months after the diagnosis. This rare case highlights the challenges of managing unresectable primary duodenal dedifferentiated liposarcoma but suggests that radiotherapy and systemic therapy can provide temporary control and symptom relief.
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