Related Experiment Video
Updated: Sep 18, 2025
12:20
Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
Published on: December 29, 2015
21.5K
Spatiotemporal Distribution and Host-Vector Dynamics of Japanese Encephalitis Virus.
Qikai Yin1, Bin Li2, Ruichen Wang1
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Viruses
|June 27, 2025
Summary
Japanese encephalitis virus (JEV) transmission dynamics are changing, with new genotypes emerging. Enhanced surveillance is crucial to manage risks from JEV genotype diversity and spread.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Japanese encephalitis (JE) is a significant mosquito-borne viral disease in Asia, caused by the Japanese encephalitis virus (JEV).
- Vaccination has reduced JE incidence, but challenges remain, particularly in adults, with emerging JEV genotypes posing new risks.
Purpose of the Study:
- To analyze changes in JEV transmission dynamics before and after 2012.
- To examine JEV genotype diversity, host-vector interactions, and geographic spread.
Main Methods:
- Phylogenetic analysis of whole JEV genome sequences.
- Temporal-spatial analysis of JEV isolates.
- Host-vector analysis, including identification of vectors and amplifying hosts.
Main Results:
- Persistent differences observed between dominant G1 and G3 JEV genotypes.
- Re-emergence of rare JEV genotypes G4 and G5 noted.
- Culex tritaeniorhynchus mosquitoes and pigs confirmed as primary vector and amplifying host, despite detection in non-traditional hosts/vectors.
Conclusions:
- Enhanced surveillance for JEV genotype diversity is necessary.
- Strategies must address emerging threats from JEV genotype expansion, host range, and geographic spread to mitigate public health risks.
